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甲状旁腺素促成骨作用的研究进展

李宁王满宜贺良*

【摘要】甲状旁腺素(Parathyroid hormone,PTH)能够调节骨骼的合成代谢和分解代谢过程,通过影响包括成骨细胞、破骨细胞、骨骼内衬细胞、骨细胞等众多种类的细胞系,并激活多种信号途径,从而达到促进骨形成的作用。这取决于低剂量及间断性的给药方式。大量动物试验和临床研究,显示甲状旁腺素可有效的治疗骨质疏松。近年来动物实验发现甲状旁腺素也可有效的促进骨折愈合。甲状旁腺素作为骨形成促进剂,将广泛应用于临床治疗。

【关键词】 甲状旁腺素;骨质疏松;骨折愈合;骨形成

【中图分类号】 R683

【文献标识码】 A

作者单位:北京积水潭医院,创伤骨科,100035

通讯作者:贺良[email protected]

Advances in Research of the Anabolism Effect of Parathyroid Hormone

Li Ning, Wang Man-yi, He Liang*

[Abstract] Parathyroid hormone regulates skeletal anabolism and catabolism, and promotes osteogenesis through intervening in various cell lines including osteoblasts, osteoclasts, bone lining cells and osteocytes, and activating multiple signaling pathways. This effect depends on intermittent low-dose administration. Numerous animal and clinical trials indicate parathyroid hormone can treat osteoporosis effectively. Recently, it has been discovered in animal trials that parathyroid hormone could also promote fracture healing effectively. Parathyroid hormone may be widely utilized in clinic as an osteogenetic promoter.

[Key words] parathyroid hormone; osteoporosis; fracture healing; osteogenesis

Author′s unit: Department of orthopedics and traumatology, Beijing Jishuitan Hospital, 100035
Corresponding author: He Liang,
[email protected]

中国骨质疏松杂志,2009,15(10):778-783

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